Downregulation of CFTR Is Involved in the Formation of Hypertrophic Scars

Figure 4

CFTR deficiency in fibroblasts can affect collagen production under mechanical overloading conditions. (a) Without mechanical overloading, the expression of Col1 was the same in WT and ΔF508 fibroblasts, and the expression of Col3 was significantly lower in ΔF508 fibroblasts compared to that in WT fibroblasts. (b) Under mechanical overloading conditions, the expression of Col1 was significantly higher and Col3 was the same, resulting in a higher ratio of Col1/Col3 in ΔF508 fibroblasts compared to that in WT fibroblasts. .

(a)

(b)