Safety Assessment of High- and Low-Molecular-Weight Hyaluronans (Profhilo®) as Derived from Worldwide Postmarketing Data
Table 4
Recommendations in case of AEs occurring after dermal filler injection, according to the most recent guidelines.
AEs
Treatment
Early onset (<72 hours)
(i) Bruising, edema, bleeding, redness, swelling
Cold compresses, no exercise for 24 h
(ii) Tyndall effect
Hyaluronidaseand massage
(iii) Lumping, superficial placement
Hyaluronidaseand massage
(iv) Abscess
Antibiotic (amoxicillin+clavulanate; cephalexin; ciprofloxacin); incision and drainage
Late onset (>72 hours)
(i) Displacement
Hyaluronidase
(ii) Nodule
Hyaluronidase; antibiotic therapy (clarithromycin+moxifloxacin; ciprofloxacin; minocycline) and steroid (in case of infection); excision
(iii) Biofilm
Antibiotic therapy after culture
(iv) Granuloma
Hyaluronidase; antibiotic therapy (clarithromycin+moxifloxacin; ciprofloxacin; minocycline) and steroid (in case of infection); incision and drainage
(Adapted from Signorini et al. 2016 and W.G. Philipp-Dormston et al. 2017). From 10 to 20 U single injection up to four injection points according to the extension of the area.