Safety Assessment of High- and Low-Molecular-Weight Hyaluronans (Profhilo®) as Derived from Worldwide Postmarketing Data

Table 1

HA dermal filler AEs.

Early-onset AEs (<72 hrs)	Late-onset AEs (>72 hrs)
(i) Injection site reactions: edema, pain, erythema, itching, bleeding, ecchymosis	(i) Late infection: biofilm and fibrosis; (ii) Inflammatory nodule or granuloma
(ii) Displacements: lumps, asymmetries, contour deformities	(iii) Noninflammatory nodule
(iii) Hypersensitivity reaction	(iv) Altered pigmentation; (v) Scarring
(iv) Early acute infection: HSV, abscess, cellulitis
(v) Tyndall effect
(vi) Thromboembolism