Review Article

The Effect of Autologous Platelet Concentrates on Maxillary Sinus Augmentation: A Meta-Analysis of Randomized Controlled Trials and Systematic Review

Table 1

(a) Characteristics of the included studies

References (year)Study design (duration)CountryNo. of patients (sinus)Intervention (no. of patients)Sex (no. of patients)Age (years)

Nizam et al. (2018) [16]RCT/a split-mouth (12 months)Turkey13 (26)TG: 13/CG: 134 F/9 M
Olgun et al. (2018) [15]RCT/parallel (6 months)Turkey18 (18)TG: 10/CG: 89 F/9 M42-69
Cömert Kılıç et al. (2017) [17]RCT/parallel (6 months)Turkey26 (26)TG: 17/CG: 99 F/17 M22-51
Taschieri et al. (2016) [18]RCT/a split-mouth design (6 months)Italy5 (10)TG: 5/CG: 53 F/2 M48-71
Zhang et al. (2012) [20]RCT/parallel (6 months)China10 (11)TG: 6/CG: 52 F/8 M30-53
Kassolis and Reynolds (2005) [24]RCT/a split mouth (6 months)U.S10 (20)TG: 10/CG: 10NR22-58
Khairy et al. (2013) [19]RCT/parallel (6 months)Egypt15 (15)TG: 10/CG: 5NR22-54
Pichotano et al. (2019) [14]RCT/a split-mouth (8 months)Brazil12 (24)TG: 12/CG: 126 F/6 M43-63
Thor et al. (2007) [21]RCT/a split-mouth (6 months)Sweden11 (22)TG: 11/CG: 1110 F/1 M36-72
Raghoebar et al. (2005) [23]RCT/a split-mouth ()The Netherlands5 (10)TG: 5/CG: 53 F/2 M57-62
Consolo et al. (2007) [22]RCT/a split-mouth (4-7 months)Italy16 (32)TG: 16/CG: 1611 F/5 M37-57

(b) Characteristics of the included studies

References (year)APC preparation, the kind and use of the APCsSurgical procedureComplications and prognosis

Nizam et al. (2018) [16]Peripheral blood, 400×g/12 min, L-PRF membrane cut into fragments to mix with DBBM, L-PRF, and membraneTG: the maxillary sinus augmentation procedure was randomly performed using DBBM +L-PRF mixture.
CG: the maxillary sinus augmentation procedure was randomly performed using DBBM alone
A significant bleeding with control

Olgun et al. (2018) [15]T-PRF: the blood (20 ml) is centrifuged in titanium tubes (878 g, 12 minutes), PRF membraneTG: to augment the sinus floor by T-PRF alone and implant after 4 months
CG: to augment the sinus floor by allografts alone and implant after 6 months
No

Cömert Kılıç et al. (2017) [17]PRP: 10 ml blood with anticoagulant, 3000 rpm/10 min. classification of Donhan Ehrenfest
PRF: 10 ml blood, 3000 rpm/10 min, PRF membrane
TG: the maxillary sinus-floor elevation with PRF+ β-TCP mixture grafts or the maxillary sinus-floor elevation with P-PRP+ β-TCP mixture grafts.
CG: the maxillary sinus-floor elevation with β-TCP alone.
5 sinus perforations with collagen membrane covered

Taschieri et al. (2016) [18]580g/8 min, a P-PRP gelTG: The maxillary sinus floor augmentation surgery with lateral window approach with DBBM and PRP
CG: The maxillary sinus floor augmentation surgery with lateral window approach with DBBM alone
No

Zhang et al. (2012) [20]300 g for 10 min, PRF membrane and fragmentTG: The maxillary sinus floor augmentation surgery by the lateral wall with Bio-Oss and PRF
CG: The maxillary sinus floor augmentation surgery by the lateral wall with Bio-Oss alone
No

Kassolis and Reynolds (2005) [24]80 ml blood, centrifuged for approximately 1 minute and separating the red cell component at the bottom result in PRPTG: maxillary sinus augmentation with FDBA+PRF
CG: maxillary sinus augmentation with FDBA
No

Khairy et al. (2013) [19]20 ml blood for PRP, 5600 rpm/15 min and 2400 rpm/10 min. combined with the corticocancellous particulate into the elevated sinus.TG: maxillary sinus augmentation with autogenous bone+PRF and implant insertion at4 or 6 months
CG: maxillary sinus augmentation with autogenous bone and implant insertion at 6 months
5 patients of sinus perforation with control

Pichotano et al. (2019) [14]20 ml blood, 300 g/10 min, L-PRF membraneTG: the bilateral maxillary sinus augmentation with DBBM +PRF and implant insertion at 4 months
CG: the bilateral maxillary sinus augmentation with DBBM and implant insertion at 6 months
No

Thor et al. (2007) [21]450 ml blood of whole blood from a peripheral vein of the arm or foot, 5600 rpm and 2400 rpm for PRPTG: the left side of maxillary sinus augmentation with particulated autogenous bone + PRP and implant insertion at 3 months
CG: he left side of maxillary sinus augmentation with particulated autogenous bone alone and implant insertion at 3 months
No

Raghoebar et al. (2005) [23]60 ml blood of whole blood with the TGF-β concentration according to the method described by Waarde for PRPTG: the one side of maxillary sinus augmentation with autogenous bone +PRP and implant insertion at 3 months
CG: the left side of maxillary sinus augmentation with autogenous bone alone and implant insertion at 3 months
One implant with removed and one sinus perforation with healing

Consolo et al. (2007) [22]450 ml blood of whole blood with container containing an anticoagulant for PRP, 1200 g/6 min at 20°C and 4400 g/6 min at 14°C.TG: the one side of maxillary sinus augmentation with autogenous bone +PRP and implant insertion at 4-7 months
CG: the other side of maxillary sinus augmentation with autogenous bone alone and implant insertion at 4-7 months
No

CG: control group; TG: test group; L-PRF: leukocyte-and platelet-rich fibrin (L-PRF); DBBM: deproteinized bovine bone mineral; NR: not report.