Association between Renal Podocalyxin Expression and Renal Dysfunction in Patients with Diabetic Nephropathy: A Single-Center, Retrospective Case-Control Study

Table 3

Associations of podocalyxin expression in renal tissues and urinary podocalyxin/urine creatinine ratio with the clinicopathological characteristics of patients with diabetic nephropathy.

	Renal podocalyxin expression		Urinary podocalyxin/urinary creatinine
	Correlation coefficient	value	Correlation coefficient	value
Age (years)	-0.127	0.489	0.222	0.221
Diabetes course (months)	-0.273	0.137	0.162	0.376
Nephropathy course (months)	-0.155	0.389	0.012	0.949
Mean arterial pressure (mmHg)	-0.151	0.408	0.072	0.649
HbA1c (%)	-0.706	<0.001	0.534	0.002
FPG (mmol/L)	-0.206	0.257	0.209	0.25
Triglycerides (mmol/L)	-0.203	0.264	0.304	0.091
Cholesterol (mmol/L)	-0.112	0.541	0.102	0.578
Albumin (g/L)	0.559	0.001	-0.629	<0.001
NAG (U/L)	-0.205	0.260	0.343	0.05
Urine protein (g/24 h)	-0.513	0.003	0.764	<0.001
Serum creatinine (μmol/L)	-0.629	<0.001	0.614	<0.001
eGFR	0.604	<0.001	-0.677	<0.001
Glomerular grade	-0.108	0.556	0.268	0.138
IFTA	-0.325	0.069	0.49	0.004
Renal interstitial inflammation	-0.547	0.001	0.562	0.001
Renal arteriosclerosis	-0.386	0.029	0.441	0.011
Podocalyxin	-0.691	<0.001	-0.695	<0.001

eGFR: estimated glomerular filtration rate; FPG: fasting plasma glucose; HbA1c: glycated hemoglobin; IFTA: tubular atrophy and interstitial fibrosis; NAG: N-acetyl-beta-D-glucosaminidase.