Identification of Key Genes of Human Advanced Diabetic Nephropathy Independent of Proteinuria by Transcriptome Analysis

Figure 4

PPI network and modules constructed by cytoscape. PPI network of upregulated DEGs in glomerular (a) and tubulointerstitial (d) compartments and downregulated DEGs in tubulointerstitium (g). Hub genes were selected by MCC algorithms using cytoHubba plugin. The top 30 ranked DEGs were shown with a color scheme from highly essential (red) to essential (yellow). The most (b) and second significant clusters (c) of upregulated DEGs in glomeruli identified by MCODE plugin. The most (e) and second significant clusters (f) of upregulated DEGs in tubulointerstitium. (h) The most significant cluster of downregulated DEGs in tubulointerstitium. DEGs: differentially expressed genes; PPI: protein-protein interaction.