Overall Postoperative Morbidity and Pancreatic Fistula Are Relatively Higher after Central Pancreatectomy than Distal Pancreatic Resection: A Systematic Review and Meta-Analysis

Table 2

Results of meta-analysis: CP versus DP.

Outcome of interest	Studies no.	Patients no. (CP/DP)	RR or SMD	95% CI	value	I^2 (%)	Model
Intraoperative outcomes
Operation time (min)	20	526/911	1.03	(0.62, 1.44)	<0.001	90%	Random effects
EBL (ml)	18	478/793	−0.34	(−0.58,−0.09)	0.007	70.6%	Random effects
Transfusion (n)	13	361/623	0.69	(0.47, 1.01)	0.059	0.0	Fixed effects
Postoperative outcomes
LOS (days)	23		0.63	(0.20, 1.05)	<0.01	90.8%	Random effects
Overall complications	21	499/1002	1.30	(1.13, 1.50)	<0.001	0.0	Fixed effects
Overall PF	24	593/1226	1.41	(1.20, 1.66)	<0.001	0.0	Fixed effects
PF (grade B + C)	12	350/825	1.64	(1.25, 2.16)	<0.001	1.7	Fixed effects
POH	11	373/567	1.90	(1.18, 3.06)	0.008	0.0	Fixed effects
Reoperation (n)	15	411/805	1.10	(0.69, 1.73)	0.699	6.1	Fixed effects
Perioperative mortality	3	63/163	3.31	(0.52, 21.32)	0.207	0.0	Fixed effects
Long-term outcomes
Endocrine impairment	18	483/694	0.27	(0.18, 0.40)	<0.001	0.0	Fixed effects
IDDM	6	227/163	0.15	(0.06, 0.42)	<0.001	0.0	Fixed effects
Exocrine impairment	9	304/324	0.56	(0.37, 0.84)	0.006	0.0	Fixed effects
Recurrence	7	155/366	1.02	(0.48, 2.20)	0.956	0.0	Fixed effects

EBL: estimated blood loss; LOS: length of hospital stay; PF: pancreatic fistula; POH: postoperative hemorrhage; IDDM: insulin-dependent diabetes mellitus.