Exploring the Key Genes and Pathways in the Formation of Corneal Scar Using Bioinformatics Analysis

Table 1

The top 10 Gene Ontology (GO) functions and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways enriched for the genes involved in module 2.

Description	Value	Count	Gene symbol
GO:0007186 G-protein coupled receptor protein signaling pathway (BP)	1.25E-07	11	GRM5, LTB4R1, CYSLTR1, TACR3, EDN1, OXTR, PROKR1, GPR143, NMBR, HTR2B, OPN4
GO:0007166 cell surface receptor linked signal transduction (BP)	1.97E-06	11	GRM5, LTB4R1, CYSLTR1, TACR3, EDN1, OXTR, PROKR1, GPR143, NMBR, HTR2B, OPN4
GO:0008528 peptide receptor activity, G-protein coupled (MF)	6.35E-05	4	TACR3, OXTR, PROKR1, NMBR
GO:0042277 peptide binding (MF)	1.93E-04	4	TACR3, OXTR, PROKR1, NMBR
GO:0008188 neuropeptide receptor activity (MF)	3.53E-04	3	TACR3, PROKR1, NMBR
GO:0042165 neurotransmitter binding (MF)	0.001843	3	TACR3, PROKR1, NMBR
GO:0004974 leukotriene receptor activity (MF)	0.003007	2	LTB4R1, CYSLTR1
GO:0003013 circulatory system process (BP)	0.004138	3	EDN3, EDN1, OXTR
GO:0005886 plasma membrane (CC)	0.009375	8	GRM5, LTB4R1, CYSLTR1, TACR3, OXTR, PROKR1, NMBR, HTR2B
GO:0042310 vasoconstriction (BP)	0.011425	2	EDN3, EDN1
mmu04080: Neuroactive ligand-receptor interaction	5.51E-08	7	GRM5, LTB4R1, CYSLTR1, TACR3, OXTR, NMBR, HTR2B
mmu04020: Calcium signaling pathway	3.85E-05	5	GRM5, CYSLTR1, TACR3, OXTR, HTR2B