Negative Regulation of Tec Kinase Alleviates LPS-Induced Acute Kidney Injury in Mice via theTLR4/NF-κB Signaling Pathway

Figure 3

LFM-A13 pretreatment alleviates LPS-induced AKI. In the LPS group, mice were i.p. injected with LPS (20 mg/kg). In the LFM-A13+LPS group, mice were pretreated with LFM-A13 dose (40, 60, and 80 mg/kg) immediately after LPS injection. Blood samples and kidney tissues were collected at 24 h after LPS i.p. (a–c) Renal function including BUN, sCr, and Cys-C was measured 24 h after LPS injection. (d) Renal histopathology was evaluated 24 h after LPS injection. An obvious renal pathological damage, including tubular cell swelling, dilatation, lysis, destruction of tubular structures, and neutrophil emigration (solid arrows), was observed after LPS treatment. . (e) Pathological scores of tubular damage among different groups. All data were expressed as the . , .

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