A New Risk Polymorphism rs10403848 of CARD8 Significantly Associated with Psoriasis Vulgaris in Northeastern China

Table 5

The single SNP association studies result of CARD8 for the four variants in cases and controls.

SNP	Genotype	Cases (n = 540)	Controls (n = 612)	H-W P	Statistical model			OR (95%CI)
rs2043211	TT	118 (0.219)	140 (0.229)		Codominant	0.9343	0.9491
	TA	282 (0.522)	310 (0.506)		Additive	0.9268	0.9284	1.010
	AA	140 (0.259)	162 (0.265)	0.8727	Dominant	0.7686	0.8411	(0.801, 1.273)
	T/A	518/562	590/634		Recessive	0.8821	0.9237
		0.480/0.520	0.482/0.518		Heterozygous	0.7070	0.7328
rs2288876	GG	30 (0.056)	30 (0.049)		Codominant	0.5251	0.5328
	GA	220 (0.407)	238 (0.389)		Additive	0.8168	0.8158	0.919
	AA	290 (0.537)	344 (0.562)	0.6794	Dominant	0.7249	0.8551	(0.704, 1.201)
	G/A	280/800	298/926		Recessive	0.5464	0.5559
		0.259/0.741	0.243/0.757		Heterozygous	0.6505	0.6676
rs3745718	TT	300 (0.556)	328 (0.536)		Codominant	0.9617	0.9999
	TC	206 (0.381)	256 (0.418)		Additive	0.5029	0.5123	0.994
	CC	34 (0.063)	28 (0.046)	0.5818	Dominant	0.6372	0.6758	(0.762, 1.296)
	T/C	806/274	912/312		Recessive	0.3615	0.4544
		0.746/0.254	0.745/0.255		Heterozygous	0.3681	0.3930
rs10403848	GG	244 (0.452)	318 (0.520)		Codominant	0.4950	0.5089
	GA	260 (0.481)	234 (0.382)		Additive	0.0418	0.0411	1.091
	AA	36 (0.067)	60 (0.098)	0.3829	Dominant	0.1043	0.1080	(0.847, 1.405)
	G/A	748/332	870/354		Recessive	0.1713	0.1800
		0.693/0.307	0.711/0.289		Heterozygous	0.0164	0.0159

H-W, Hardy–Weinberg equilibrium test; , value; , value adjusted by permutation; OR, odds ratio; 95% CI, 95% confidence interval, ^∗the significant association.