CTLA4-Ig Abatacept Ameliorates Proteinuria by Regulating Circulating Treg/IL-17 in Adriamycin-Induced Nephropathy Rats

<div>AIN was induced by tail vein injection of adriamycin in rats. It is characterized by proteinuria (a), hypoalbuminemia (b), and hypercholesterolemia (c). Proteinuria was reduced using prednisone (d). 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172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,61.846,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg><i> vs</i>. the Nor group. Nor: normal group; AIN: adriamycin-induced nephropathy group. HE staining showed glomerular morphology with minimal alterations ((d) original magnification ×100; (e) original magnification ×400); electron microscopy showed foot-process effacement ((g) original magnification ×2500; (f) original magnification ×12000).</div>

BioMed Research International

fig1

Figure 1

Figure 1: CTLA4-Ig Abatacept Ameliorates Proteinuria by Regulating Circulating Treg/IL-17 in Adriamycin-Induced Nephropathy Rats 