Altered Expression of Long Noncoding and Messenger RNAs in Diabetic Nephropathy following Treatment with Rosiglitazone

Figure 6

Representative significantly enriched gene sets from GSEA for the global mRNA expression profile. Upregulated gene sets identified in dbdb mice (a–d) and upregulated genes in control mice (e, f) following analysis of dbdb compared to control groups. Upregulated gene sets in dbR mice (g, h), and upregulated genes in dbdb mice (i–l) following analysis of dbR compared to dbdb group. In every thumbnail, the green curve represents the evolution of the density of the genes identified in the RNA-seq. The false discovery rate (FDR) is calculated by comparing the actual data with 1000 Monte Carlo simulations. The NES (normalized enrichment score) computes the density of modified genes in the dataset with the random expectancies, normalized by the number of genes found in a given gene cluster, to account for the size of the cluster.

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