Altered Expression of Long Noncoding and Messenger RNAs in Diabetic Nephropathy following Treatment with Rosiglitazone

Figure 2

Differentially expressed mRNAs and lncRNAs in the renal cortices of diabetic nephropathic mice. Volcano plot for comparison of (a) mRNA expression between the dbdb and control group, (b) mRNA expression between the dbR and dbdb group, (d) lncRNA expression between the dbdb and control group, and (e) lncRNA expression between the dbR and dbdb group. On the right side, the red color is indicative of the upregulated genes (q < 0.05); on the left side, the green color is indicative of the downregulated gene (q < 0.05). The blue points indicate mRNAs that were not statistically significant (q > 0.05). Venn diagrams illustrate the number of significantly differentially expressed (c) mRNAs and (f) lncRNAs. The overlapping areas represent the coregulated genes in both dbdb/control and dbR/dbdb analyses. Differentially expressed (g) mRNAs and (h) lncRNAs (q < 0.05) in dbdb/control or dbR/dbdb analyses were assessed using hierarchical clustering. Each row represents a single gene expression, and each column represents one tissue sample.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)