Prognostic Value of Concurrent Expression of C-MYC and BCL2 in Intravascular Large B-Cell Lymphoma: A 10-Year Retrospective Study
Table 1
Summary of clinical characteristics, laboratory investigation, and therapeutic response in IVLBCL patients.
No.
Sex, age (years)
Presenting symptoms
Duration (weeks)
Skin lesions
BM involvement
Other associated symptoms
Diagnostic tissue from other organs
LDH (U/L)
Ferritin (ng/mL)
IPI score
Treatment
Result after initial treatment
Status at last follow-up
Total follow-up time (months)
1
M, 61
Fever
12
No
Yes
Dyspnea
—
592
2369
5
R-CHOP
CR
AW
8
2
M, 61
Fever
8
No
Yes
—
Lungs (bronchoalveolar lavage)
848
NA
4
CHOP
CR
AW
14
3
M, 77
Fever
5
No
No
—
—
1142
1596.2
4
CHOP
PD
DWD
0.5
4
F, 65
Fever
12
No
No
Dyspnea, motor neuropathy
—
1047
35766.4
4
R-CHOP
CR
AW
26
5
M, 57
Fever
12
No
No
—
—
811
7494
3
CHOP
CR
AW
12
6
F, 69
Fever
8
No
No
—
—
708
2123.4
4
R-CHOP
CR
AW
20
7
F, 65
Fever
12
Yes
No
Hepatosplenomegaly, alteration of consciousness
—
1154
NA
4
CHOP⟶transferred
CR⟶R⟶PD
AWD
26
8
F, 54
Fever
NA
No
Yes
Hepatosplenomegaly, cauda equina syndrome
—
NA
NA
NA
ESHAP, hyper-CVAD
PD
DWD
18
9
M, 59
Fever
4
No
No
Hepatomegaly
—
NA
NA
NA
CHOP
PD
DWD
0.5
10
F, 80
Fever
4
No
Yes
—
—
528
4629.4
5
R-CHOP
PT
AWD
4.5
11
M, 77
Fever
1
Yes
No
Splenomegaly
Maxillary and ethmoid sinus
1481
1891.2
5
CHOP
PD
DWD
3
12
F, 59
Alteration of consciousness
4
Yes
No
Dyspnea
—
317
1888
4
CHOP
PR
DWD
10
13
F, 56
Dementia
12
No
No
—
Brain
346
342.8
4
R-CHOP
CR
AW
21
14
M, 77
Progressive paralysis
8
No
No
Dyspnea
—
565
NA
4
Transferred
Transferred
AWD
4
15
M, 83
Alteration of consciousness
8
Yes
Yes
—
—
6763
2582.1
5
CHOP
PD
DWD
2
16
M, 64
Abdominal pain and jaundice
2
No
Yes
Hepatosplenomegaly
—
1362
NA
5
Transferred
Transferred
AWD
0.5
17
M, 81
Anorexia
8
No
No
—
—
1246
2505
4
R-CHOP
CR
AW
18
Abbreviations used: BM: bone marrow; IPI: international prognostic index; LDH: lactate dehydrogenase; M: male; F: female; NA: data not available; R-CHOP = rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone; CHOP: cyclophosphamide, doxorubicin, vincristine, and prednisolone; ESHAP: etoposide, methylprednisolone, high-dose cytarabine, and cisplatin; Hyper-CVAD: cyclophosphamide, vincristine, doxorubicin, and dexamethasone; CR: complete remission; PD: progressive disease; PT: in the period of treatment; R: relapse; PR: partial remission; AW: alive and well; DWD: dead with disease; AWD: alive with disease. Normal serum U/L. Normal serum ng/mL.