Prognostic Value of Concurrent Expression of C-MYC and BCL2 in Intravascular Large B-Cell Lymphoma: A 10-Year Retrospective Study

Table 1

Summary of clinical characteristics, laboratory investigation, and therapeutic response in IVLBCL patients.

No.	Sex, age (years)	Presenting symptoms	Duration (weeks)	Skin lesions	BM involvement	Other associated symptoms	Diagnostic tissue from other organs	LDH (U/L)	Ferritin (ng/mL)	IPI score	Treatment	Result after initial treatment	Status at last follow-up	Total follow-up time (months)
1	M, 61	Fever	12	No	Yes	Dyspnea	—	592	2369	5	R-CHOP	CR	AW	8
2	M, 61	Fever	8	No	Yes	—	Lungs (bronchoalveolar lavage)	848	NA	4	CHOP	CR	AW	14
3	M, 77	Fever	5	No	No	—	—	1142	1596.2	4	CHOP	PD	DWD	0.5
4	F, 65	Fever	12	No	No	Dyspnea, motor neuropathy	—	1047	35766.4	4	R-CHOP	CR	AW	26
5	M, 57	Fever	12	No	No	—	—	811	7494	3	CHOP	CR	AW	12
6	F, 69	Fever	8	No	No	—	—	708	2123.4	4	R-CHOP	CR	AW	20
7	F, 65	Fever	12	Yes	No	Hepatosplenomegaly, alteration of consciousness	—	1154	NA	4	CHOP⟶transferred	CR⟶R⟶PD	AWD	26
8	F, 54	Fever	NA	No	Yes	Hepatosplenomegaly, cauda equina syndrome	—	NA	NA	NA	ESHAP, hyper-CVAD	PD	DWD	18
9	M, 59	Fever	4	No	No	Hepatomegaly	—	NA	NA	NA	CHOP	PD	DWD	0.5
10	F, 80	Fever	4	No	Yes	—	—	528	4629.4	5	R-CHOP	PT	AWD	4.5
11	M, 77	Fever	1	Yes	No	Splenomegaly	Maxillary and ethmoid sinus	1481	1891.2	5	CHOP	PD	DWD	3
12	F, 59	Alteration of consciousness	4	Yes	No	Dyspnea	—	317	1888	4	CHOP	PR	DWD	10
13	F, 56	Dementia	12	No	No	—	Brain	346	342.8	4	R-CHOP	CR	AW	21
14	M, 77	Progressive paralysis	8	No	No	Dyspnea	—	565	NA	4	Transferred	Transferred	AWD	4
15	M, 83	Alteration of consciousness	8	Yes	Yes	—	—	6763	2582.1	5	CHOP	PD	DWD	2
16	M, 64	Abdominal pain and jaundice	2	No	Yes	Hepatosplenomegaly	—	1362	NA	5	Transferred	Transferred	AWD	0.5
17	M, 81	Anorexia	8	No	No	—	—	1246	2505	4	R-CHOP	CR	AW	18

Abbreviations used: BM: bone marrow; IPI: international prognostic index; LDH: lactate dehydrogenase; M: male; F: female; NA: data not available; R-CHOP = rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone; CHOP: cyclophosphamide, doxorubicin, vincristine, and prednisolone; ESHAP: etoposide, methylprednisolone, high-dose cytarabine, and cisplatin; Hyper-CVAD: cyclophosphamide, vincristine, doxorubicin, and dexamethasone; CR: complete remission; PD: progressive disease; PT: in the period of treatment; R: relapse; PR: partial remission; AW: alive and well; DWD: dead with disease; AWD: alive with disease. Normal serum  U/L. Normal serum  ng/mL.