Different Numbers of Long-Pulse 1064-nm Nd-YAG Laser Treatments for Onychomycosis: A Pilot Study
Table 3
Efficacy rates among the different groups.
Clinical efficacy rate
Group A ()
Group B ()
Group C ()
Week 8
Total
55 (35.5%)
55 (31.4%)
31 (27.7%)
0.095
Clinical type
DLSO
46 (42.6%)
39 (37.9%)
27 (34.2%)
WSO
6 (30.0%)
9 (34.6%)
1 (33.3%)
PSO
1 (11.1%)
2 (33.3%)
0%
TDO
2 (11.1%)
5 (12.5%)
3 (11.1%)
Severity of infected nails
II
47 (62.7%)
46 (52.3%)
28 (49.1%)
III
8 (10.0%)
9 (10.3%)
3 (5.5%)
Location of infected nails
Fingernail
4 (23.5%)
9 (23.1%)
4 (26.7%)
Toenail
51 (37.0%)
46 (33.8%)
27 (27.8%)
Week 16
Total
60 (38.7%)
73 (41.7%)
56 (50.0%)
0.172
Clinical type
DLSO
51 (47.2%)
55 (53.4%)
42 (53.2%)
WSO
6 (30.0%)
11 (42.3%)
3 (100.0%)
PSO
1 (11.1%)
3 (50.0%)
1 (33.3%)
TDO
2 (11.1%)
4 (10.0%)
10 (37.0%)
Severity of infected nails
II
53 (70.7%)
62 (70.5%)
37 (64.9%)
III
7 (8.8%)
11 (12.6%)
19 (34.6%)
Location of infected nails
Fingernail
7 (41.2%)
13 (33.3%)
7 (46.7%)
Toenail
53 (38.4%)
60 (44.1%)
49 (50.5%)
Week 24
Total
58 (37.4%)
77 (44.0%)
62 (55.4%)
0.014
Clinical type
DLSO
51 (47.2%)
54 (52.4%)
45 (57.0%)
WSO
6 (30.0%)
11 (42.3%)
3 (100.0%)
PSO
0
2 (33.3%)
1 (33.3%)
TDO
1 (5.6%)
10 (25.0%)
13 (48.2%)
Severity of infected nails
II
54 (72.0%)
58 (65.9%)
41 (71.9%)
III
4 (5.0%)
19 (21.8%)
21 (38.2%)
Location of infected nails
Fingernail
7 (41.2%)
13 (33.3%)
8 (53.3%)
Toenail
51 (37.0%)
64 (47.1%)
54 (55.7%)
Group A: four sessions; Group B: eight sessions; Group C: 12 sessions. DLSO: distal lateral subnail onychomycosis; WSO: white superficial onychomycosis; PSO: proximal subnail onychomycosis; TDO: total dystrophy onychomycosis. The clinical efficacy rate was defined as the total percentage of nails with complete response and significant response. “Complete response or cure” was defined as fully normal appearing nail measured from the proximal nail fold to involved nail; “significant response” was defined as >60% normal-appearing nail compared with the area of the initially infected nail; “moderate response” was defined as 20–60% normal-appearing nail; and “no response” was defined as <20% normal-appearing nail. , group A vs. group C (Bonferroni correction: 0.05/3). There were no significant differences for group A vs. group B and group B vs. group C.
