Review Article
Pharmacological Protection of Kidney Grafts from Cold Perfusion-Induced Injury
Table 1
Pharmacological strategies in the prevention of kidney ischemia-reperfusion.
| Study | Species | Model | Ischemia (min) | Reperfusion | Inhibitor | Dose | Effect on kidney function |
| [5] | Knockout MMP-2−/− mice | In vivo | 60 | 24h | Minocycline | 45mg/kg | ↓ ATI ↓ Renal dysfunction | [5] | Knockout MMP-2−/− mice | In vivo | 60 | 24h | MMP-2/MMP-9 Inhibitor III | 2.5mg/kg | ↓ ATI ↓ Renal dysfunction | [6] | Rat | In vivo | 10 | - | Doxy | 100µM | ↓ LDH ↓ NGAL ↓ Cco | [6] | Rat | In vivo | 10 | - | MMP-2 siRNA | 10µM
| ↓ LDH ↓ NGAL ↓ Cco | [7] | Rat | In vivo | 45 | 4wk | SS-20 | 2mg/kg | ↓ Cytoskeletal breakdown ↓ Mitochondria matrix swelling
| [8] | Rat | In vivo
| 60 | 6h | Taurine | 200mg/kg | ↓ Degeneration tubular architecture ↓ Inflammatory cell infiltration ↓ Renal dysfunction
| [9] | Mice | In Vivo | 45 | Up to 7 days | Everolimus | 0.25mg/kg | ↓ Kidney function ↓ Recovery of kidney function
| [10] | Pig | In vivo | 25 | 18h | 1400W | 10mg/kg | ↑ Renal function ↓ Oxidative stress
| [11] | Mice | In Vivo | 45 | Up to 24h | MitoQ | 4mg/kg | ↓ Oxidative damage
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SS-20: H-Phe-D-Arg-Phe-Lys-NH2; Taurine: 2-aminoethanesulfonic acid; Everolimus: RAD001; DOXY: doxycycline; wk: weeks; ↑: increased; ↓: decreased.
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