Hyperhomocysteinemia Associated with Low Muscle Mass, Muscle Function in Elderly Hemodialysis Patients: An Analysis of Multiple Dialysis Centers
Table 4
Stepwise regression analyses for determining muscle mass and muscle function in hemodialysis patients with hyperhomocysteinemia.
Variables
B (95% CI)
p
adjusted R2
SMM
0.84
Creatinine (mg/dL)
0.23 (0.01 to 0.45)
0.042
BMI (kg/m2)
1.02 (0.86 to 1.18)
< 0.001
Body fat (%)
-0.36 (-0.41 to -0.30)
< 0.001
0.47
Creatinine (mg/dL)
0.18 (0.07 to 0.29)
0.002
Body fat (%)
-0.04 (-0.06 to -0.02)
< 0.001
MET (kcal/day)
0.0006 (-0.0001 to 0.0012)
0.084
0.99
Homocysteine (μmol/L)
-0.03 (-0.05 to -0.01)
0.027
Creatinine (mg/dL)
0.17 (0.09 to 0.25)
< 0.001
Body fat (%)
-0.55 (-0.56 to -0.53)
< 0.001
Hand grip strength
0.35
Homocysteine (μmol/L)
-0.41 (-0.83 to 0.01)
0.058
Dialysis vintage (year)
-0.40 (-0.93 to 0.14)
0.143
eKt/V
6.65 (1.39 to 11.91)
0.014
Creatinine (mg/dL)
1.34 (0.37 to 2.32)
0.008
Energy (kcal/day)
0.0042 (0.0008 to 0.0075)
0.015
Body fat (%)
-0.19 (-0.40 to 0.02)
0.079
Muscle quality2
0.19
Homocysteine (μmol/L)
-0.18 (-0.37 to 0.02)
0.071
Dialysis vintage (year)
-0.22 (-0.46 to 0.02)
0.068
eKt/V
3.14 (0.76 to 5.53)
0.011
Creatinine (mg/dL)
0.54 (0.08 to 1.01)
0.023
Energy (kcal/day)
0.0015 (0.00005 to 0.0031)
0.045
BMI (kg/m2)
-0.47 (-0.73 to -0.21)
< 0.001
The significance levels of any potential factor for entry (SLE) and for stay (SLS) in the stepwise variable selection were set to 0.2. Age and gender were adjusted. Variables retained in the model are presented in the table. BMI, body mass index; MET, metabolic equivalent; SMM, skeletal muscle mass; Ht, height; Wt, weight.
