Hyperhomocysteinemia Associated with Low Muscle Mass, Muscle Function in Elderly Hemodialysis Patients: An Analysis of Multiple Dialysis Centers

Table 3

Stepwise regression for determining muscle mass and muscle function in hemodialysis patients.

Variables	B (95% CI)	p	adjusted R^2
SMM			0.82
Kt/V	-1.13 (-2.28 to 0.03)	0.056
Energy (kcal/day)	0.0008 (0.0001 to 0.0015)	0.034
BMI (kg/m^2)	1.03 (0.88 to 1.19)	< 0.001
Body fat (%)	-0.37 (-0.42 to -0.31)	< 0.001
MET (kcal/day)	0.0009 (-0.0002 to 0.0020)	0.102
			0.50
Homocysteine (μmol/L)	-0.02 (-0.05 to 0.01)	0.060
Creatinine (mg/dL)	0.23 (0.14 to 0.31)	< 0.001
Body fat (%)	-0.04 (-0.06 to -0.03)	< 0.001
			0.97
Homocysteine (μmol/L)	-0.03 (-0.06 to -0.01)	0.020
Creatinine (mg/dL)	0.13 (0.03 to 0.22)	0.009
Body fat (%)	-0.57 (-0.59 to -0.55)	< 0.001
Hand grip strength			0.35
Creatinine (mg/dL)	0.93 (0.18 to 1.68)	0.015
Energy (kcal/day)	0.0023 (-0.0004 to 0.0050)	0.092
Body fat (%)	-0.14 (-0.31 to 0.03)	0.101
Muscle quality^2			0.18
Dialysis vintage (year)	-0.15 (-0.35 to 0.05)	0.145
Kt/V	1.91 (-0.08 to 3.91)	0.060
Creatinine (mg/dL)	0.45 (0.06 to 0.83)	0.023
BMI (kg/m^2)	-0.58 (-0.88 to -0.29)	< 0.001
Body fat (%)	0.07 (-0.04 to 0.18)	0.190

The significance levels of any potential factor for entry (SLE) and for stay (SLS) in the stepwise variable selection were set to 0.2. Age and gender were adjusted. Variables retained in the model are presented in the table.
BMI, body mass index; MET, metabolic equivalent; SMM, skeletal muscle mass; Ht, height; Wt, weight.