Impact of Paracoccidioides brasiliensis Coinfection on the Evolution of Schistosoma mansoni-Induced Granulomatous Liver Injury in Mice

Figure 1

Representative photomicrographs of the liver tissue from control mice and those acutely infected with Schistosoma mansoni and Paracoccidioides brasiliensis. Pb: group infected with only P. brasiliensis. Sm: group infected only with S. mansoni. Sm+Pb: group coinfected with S. mansoni and P. brasiliensis.   S. mansoni egg is centrally observed in hepatic granulomas (Hematoxylin and Eosin staining, ×400 magnification, and bars= 50 μm). Adipocytes (stars) and P. brasiliensis (yeast-like forms) deposits (arrows) are clearly observed in mesentery (Grocott-Gomori methenamine silver method for fungi with hematoxylin counterstaining, ×400 magnification, and bars= 50 μm).