Differential Expression of mRNAs in the Brain Tissues of Patients with Alzheimer’s Disease Based on GEO Expression Profile and Its Clinical Significance
Table 3
TOP lowest term P value corrected with Bonferroni step-down of RAB7A and ITGB1.
CHIP
GOID
GO Term
Number of Genes
Associated genes (%)
Term P value
Term P value corrected with Bonferroni step-down
GSE4226
GO:0044403
Symbiosis, encompassing mutualism through parasitism
113
10.53122
5.98E-33
1.23E-30
GO:0016032
Viral process
109
10.62378
4.57E-32
9.32E-30
GO:0019058
Viral life cycle
74
15.16394
1.85E-31
3.76E-29
GO:0009056
Catabolic process
146
5.968929
4.54E-17
8.63E-15
GO:0034613
Cellular protein localization
121
6.547619
6.10E-17
1.15E-14
GSE18309
GO:0006955
Immune response
314
14.47672
1.25E-08
8.10E-06
GO:0040011
Locomotion
443
24.7072
8.99E-11
6.07E-08
GO:0032879
Regulation of localization
601
22.68781
8.00E-08
5.08E-05
GO:0045321
Leukocyte activation
178
13.69231
3.53E-07
2.20E-04
GO:0023052
Signaling
1386
20.76716
4.25E-07
2.64E-04
GSE1297
GO:0044699
Single-organism process
248
1.814856
1.08E-07
1.16E-05
GO:0044763
Single-organism cellular process
213
1.933551
1.77E-07
1.86E-05
GO:0048522
Positive regulation of cellular process
117
2.322811
7.89E-07
8.13E-05
GO:0048518
Positive regulation of biological process
125
2.214349
3.47E-06
3.51E-04
GO:0007154
Cell communication
139
2.078039
2.60E-05
0.002369
GSE5281
GO:0010604
Positive regulation of macromolecule metabolic process
