1. Does the trial address a clearly focused issue? 2. Was the assignment of patients to treatments randomized? 3. Were all the patients who entered the trial properly accounted for at its conclusion? Were patients, health workers and study personnel “blind” to treatment? 5. Were the groups similar at the start of the trial? 6. Aside from the experimental intervention, where the groups treated equally? 7. How large was the treatment effect? 8. How precise was the estimate of the treatment effect? 9. Can the results be applied to local population, or in your context? 10. Were all clinically important outcomes considered? 11. Are the benefits worth the harms and costs? NA-not applicable, because was no control group.