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First author, year | Animal | Wound type | Pathogen species | Probiotic(s) | Method | Outcome | Potential use for humans |
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Valdez, 2005 [61]# | Mice | Burn wound | Pseudomonas aeruginosa | Lactobacillus plantarum ATCC 10241 | Injection into burned area (105 cfu/mL injected into burned area on days 3, 4, 5, 7 and 9) | Inhibitory effect against pathogen and wound improvement | Local treatment of burn infections |
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Brachkova, 2011 [76] | Rats | Burn wound | P. aeruginosa | L. plantarum ATCC 8014 | Topical application on burned area (single dose 108 cfu/mL) | Reduction of pathogen load in wound | Intervention for prevention of multiresistant pathogen infection in burns |
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Jones, 2012 [77] | Rabbits | Ischemic wound | Staphylococcus aureus | Lactobacillus fermentum 7230 | Local application of patches designed with lyophilized probiotic microbeads (single dose of 106 cfu/mL) | Improvement of probiotic treated wounds through nitric oxide production | Chronic wounds |
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Shu, 2013 [68]# | Mice | Skin lesion | MRSA USA300 | Propionibacterium acnes ATCC6919 | Local topical application of Propionibacterium (105 cfu/mL for 17 days) | Decrease in cfu of pathogen | Skin wound and skin health |
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Argenta, 2016 [78] | Mice | Burn-sepsis wound | P. aeruginosa | L. plantarum ATCC 10241 | Subeschar injection (109 cfu/mL daily for 5 days) | Lower mortality rate and inhibition of pathogen in remote organs | Management of complicated burn injury |
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Satish, 2017 [79] | Rabbits | Burn-sepsis wound | P. aeruginosa | L. plantarum ATCC 10241 | Local application (single dose of 3 × 108 cfu) | Curtailed severity and length of infection as well as reduced scarring | Counteracting burn wound infection and alleviate scarring |
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Ong, 2019 [80] | Rats | Full-thickness wound | S. aureus | L. plantarum USM8613 | Single local application of 10% (v/v) protein-rich fraction of cell-free supernatant with paraffin | Higher reduction of pathogen with probiotic and enhanced wound healing | Inhibition of wound pathogens |
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Surmeli, 2019 [81] | Rats | Third-degree scald burn | MRSA ATCC 43300 | L. plantarum ATCC 10241 | Local application (single dose of 1 × 106 cfu/mL) | Protective role when applied before pathogen | Promising role in prevention and treatment of wound infections |
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