Elafibranor Inhibits Chronic Kidney Disease Progression in NASH Mice

Figure 8

SIRT1-activated and autophagy-mediated effects of elafibranor on 10% HFD-sera-increased oxidative stress and apoptosis in HK-2 cells. (a) Proteins/(b) mRNA levels in HK-2 cell lysates; (c) flow cytometry-assessed apoptotic cells; (d) IF image/bar graph of cubulin/LC3-II expression in HK-2 monolayer cells. ‡p<0.05 versus NC-sera group; p<0.05 versus V-group; p<0.05 versus elaf-group; p<0.05 versus rSIRT1 group.

(a)

(b)

(c)

(d)