Elafibranor Inhibits Chronic Kidney Disease Progression in NASH Mice

Figure 7

SIRT1-activated and autophagy-mediated effects of elafibranor on 10% HFD-sera-pretreated oxidative stress and apoptosis in podocytes. (a) Proteins/(b) mRNA levels in lysates of podocytes; (c) flow cytometry-assessed apoptotic cells; (d) IF image/bar graph of synaptopodin/LC3-II expression in podocytes monolayer cells. The optical section data for % of synaptopodin/cubulin/LC3-II (+) area on each slide were evaluated. ‡p<0.05 versus NC-sera group; p<0.05 versus V-group; p<0.05 versus elaf-group; p<0.05 versus rSIRT1-group.

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