Elafibranor Inhibits Chronic Kidney Disease Progression in NASH Mice

Figure 6

The suppression of renal oxidative stress was accompanied by the correction of autophagy impairment in HFD-induced CKD mice receiving chronic elafibranor treatment. For the quantitative evaluation, eight stained tissue sections slides and ten randomly taken pictures were included from each studied group. Representative IF images (200x)/bar graphs of glomerular synaptopodin (a) and renal tubules cubulin (b) expression. mRNAs expression in glomeruli (c) and renal tubules (d) fractions; (e) representative images/bar graphs of western blot for renal proteins expressions in glomeruli and tubular fractions. p<0.05 versus NC-group; p<0.05 versus HFD-group; p<0.05 versus HFD-elaf group.

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