Experimental Scedosporiosis Induces Cerebral Oedema Associated with Abscess regarding Aquaporin-4 and Nrf-2 Depletions

Figure 3

Aquaporin-4 expression in the brain. Immunohistochemical micrographs of AQP-4 labeling in several parts of the brain; cerebrum ((a)-(b)), hippocampus (c), olfactory bulb (d), brain stem (e), diencephalon (f), and cerebellum (g) and in either perivascular area ((h)-(k); ) or its blood vessel ((h)-(k); arrow) as presented by intact ((h) and (j)) or oedematous blood vessel ((i) and (k)). The expression of AQP-4 in the microabscess and percentage of its expression among cerebral areas, perivascular area, and cerebral blood vessel were also demonstrated in (l) and compared in (m) and (n), respectively. AQP-4 immunolocalization in cerebrum was significantly lower than that presented in olfactory bulb, diencephalon, and cerebellum (m). The oedematous vessel also exhibited lower AQP4 expression than intact vessel in both perivascular and vascular areas (n). : p value < 0.0001.