Preclinical Modeling of DCD Class III Donation: Paving the Way for the Increased Use of This Challenging Donor Type

Table 1

Anatomopathological evaluation of kidney histology at the end of MIII protocol (90 min).

Animal	Leukocytes Infiltrate	Tubular Dilation	Brush Border Loss	Necrosis
I	0	0	0	0
II	1	0	0	0
III	0	0	0	0
IV	0	0	0	0
V	0	0	0	0
VI	0	0	1	1
VII	0	0	0	0
VIII	0	0	1	1

Kidney cortex samples were collected at the end of the MIII protocol and processed for histological evaluation. A blind pathologist evaluated typical kidney lesions following a semi-quantitative scale. For leukocytes infiltration: 0: none; 1: light, localized; 2: light, diffuse; 3: intense, localized; 4: intense, diffuse. For Tubular dilation, brush border loss and necrosis: 0: none; 1: < 25%; 2: 25-50%; 3: 50-75%; 4: > 75%.