Ashy Dermatosis and Lichen Planus Pigmentosus: The Histopathological Differences

Table 3

Histopathological differences between AD (n = 29) and LPP (n = 71).

Histological features	AD, n (%)	LPP, n (%)	value
Epidermal atrophy	7 (24.1)	13 (18.3)	0.51
Epidermal hypergranulosis	0 (0)	25 (35.2)	<0.001
Epidermal hyperkeratosis	0 (0)	24 (33.8)	<0.001
Apoptotic keratinocytes	16 (55.2)	47 (66.2)	0.30
Basal vacuolization	27 (96.4)	55 (77.5)	0.02
(i) Focal	27 (100)	51 (92.7)
(ii) Diffuse	0 (0)	4 (7.3)
Lichenoid dermatitis	2 (7.1)	35 (49.3)	<0.001
(i) Focal	2 (100)	31 (88.6)
(ii) Diffuse	0 (0)	4 (11.4)
Superficial perivascular lymphocytic infiltration	29 (100)	68 (95.8)	0.55
(i)  Mild	26 (92.9)	45 (67.2)	0.04
(ii)  Moderate	2 (7.1)	19 (28.4)
(iii) Severe	0 (0)	3 (4.5)
Deep perivascular lymphocytic infiltration	0 (0)	5 (7.0)	0.32
Perifollicular infiltration	3 (10.3)	34 (47.9)	<0.001
Perifollicular fibrosis	3 (10.3)	25 (35.2)	0.01
Perieccrine infiltration	0 (0)	6 (8.5)	0.18
Pigmentary incontinence			0.015
(i)   Mild	3 (10.3)	1 (1.4)
(ii)  Moderate	25 (86.2)	55 (77.5)
(iii) Severe	1 (3.5)	15 (21.1)