Sirt5 Attenuates Cisplatin-Induced Acute Kidney Injury through Regulation of Nrf2/HO-1 and Bcl-2

Figure 4

Sirt5 regulated Nrf-2/HO1 and Bcl-2. Western blot showed that Sirt5 overexpression upregulated Nrf2, HO-1, and Bcl-2 and downregulated Bax, p-Drp1, and Drp1 protein expression. Sirt5 siRNA downregulated Nrf2, HO-1, and Bcl-2 and upregulated Bax, p-Drp1, and Drp1 protein expression.