Identification of Circular RNAs Regulating Islet β-Cell Autophagy in Type 2 Diabetes Mellitus

Figure 2

Identification of differentially expressed circRNAs between β-cells from normal and T2DM rat islets. (a) The heatmap depicts an intuitive graphical representation of gene expression in different samples after hierarchical clustering of all circRNAs. (b) Scatter plots of chip data assessing overall distribution of the two sets of data. The X and Y axis values in the scatter plot are the normalized signal values of the samples (log2 scaled). Portions beyond the lines indicate differentially expressed circRNA (fold change > 2.0 and values ≤ 0.5).

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