Citrus aurantium Ameliorates Cisplatin-Induced Nephrotoxicity

Table 5

Effect of crude extract of C. aurantium on urinary sodium and potassium levels in rats treated with cisplatin.

		Days of observation
Parameter	Groups	0^th day	7^th day	14^th day	21^st day
Urinary sodium (mEq/24 h)	Control	172 ± 4.0	180 ± 9.2	190 ± 7.3	170 ± 8.4
	Cisplatin	169 ± 4.5	300 ± 11	303 ± 11	347 ± 17
	Cisplatin + C. aurantium (200 mg/kg)	172 ± 8.0	261 ± 8.0	267 ± 7.8	296 ± 11
	Cisplatin + C. aurantium (400 mg/kg)	164 ± 6.2	218 ± 8.3	228 ± 8.7	247 ± 7.8
Urinary potassium (mEq/24 h)	Control	3.8 ± 0.35	3.0 ± 0.25	3.3 ± 0.35	3.5 ± 0.19
	Cisplatin	3.4 ± 0.36	4.3 ± 0.19	4.7 ± 0.29	5.1 ± 0.34
	Cisplatin + C. aurantium (200 mg/kg)	3.5 ± 0.26	3.1 ± 0.20	3.4 ± 0.24	3.6 ± 0.17
	Cisplatin + C. aurantium (400 mg/kg)	3.3 ± 0.51	1.6 ± 0.20	2.2 ± 0.27	2.8 ± 0.32

Statistical analysis was done through one-way analysis of variance (ANOVA) trailed by Bonferroni post hoc test for all groups in respective days. The results are considered significant () if . . Results were compared in a column with the respective control values.