Citrus aurantium Ameliorates Cisplatin-Induced Nephrotoxicity

Table 4

Effect of crude extract of C. aurantium on plasma sodium and potassium levels in rats treated with cisplatin.

		Days of observation
Parameter	Groups	0^th day	7^th day	14^th day	21^st day
Plasma sodium (mEq/L)	Control	139 ± 6.0	179 ± 5.9	178 ± 4.2	139 ± 6.1
	Cisplatin	146 ± 4.9	94 ± 8.0	106 ± 6.3	103 ± 6.6
	Cisplatin + C. aurantium (200 mg/kg)	144 ± 4.8	123 ± 5.9	130 ± 4.9	122 ± 7.1
	Cisplatin + C. aurantium (400 mg/kg)	149 ± 4.2	150 ± 5.5	155 ± 5.7	144 ± 6.4
Plasma potassium (mEq/L)	Control	5.9 ± 0.34	5.5 ± 0.45	6.1 ± 0.33	5.9 ± 0.27
	Cisplatin	5.7 ± 0.17	1.6 ± 0.20	2.2 ± 0.27	2.2 ± 0.28
	Cisplatin + C. aurantium (200 mg/kg)	5.7 ± 0.42	3.1 ± 0.20	3.4 ± 0.24	3.6 ± 0.17
	Cisplatin + C. aurantium (400 mg/kg)	5.8 ± 0.23	4.3 ± 0.19	4.7 ± 0.29	4.7 ± 0.33

Statistical analysis was done through one-way analysis of variance (ANOVA) trailed by Bonferroni post hoc test for all groups in respective days. The results are considered significant () if . , . Results were compared in a column with the respective control values.