Customized Scaffold Design Based on Natural Peripheral Nerve Fascicle Characteristics for Biofabrication in Tissue Regeneration

Figure 6

The establishment of the database of peripheral nerve microstructure and its application to design a biofabrication nerve graft model according to the morphological characteristics of the nerve bundle. The three-dimensional information database of the peripheral nerve fascicles microstructure was established by scanning peripheral nerve samples using a large number of imaging techniques (Micro-MRI/Micro-CT). When patients with peripheral nerve defects are encountered in the clinic, 3T MRI is used to scan the gross morphology of the nerve trunk of the healthy side and the affected side to locate the damaged area, the size of the defect, and whether the nerve branches were sent out. The model design information was extracted by matching from the database the gross size of the nerve branch and three-dimensional spatial information about the nerve bundle. A biofabrication nerve graft model of the nerve repair material was designed according to the microstructure of the nerve bundle according to the data from clinical MRI nerve trunk scanning.