Research Article
FcgRIII Deficiency and FcgRIIb Deficiency Promote Renal Injury in Diabetic Mice
Table 1
General and biochemical parameters of diabetic, high-fat, and nondiabetic control mice.
| Mice | WT | FcgRIIb-/- | FcgRIII-/- | Control | HFD | DM | WT | HFD | DM | Control | HFD | DM |
| Blood glucose (mmol/l) | 9.7±0.54 | 14.8±0.4 | 26.7±0.79 | 8.1±0.27 | 11.3±0.27 | 27.4±0.92 | 7±0.31 | 17.7±0.45 | 30.4±0.58 | body weight (g) | 24.6±0.38 | 32.9±0.78 | 27.7±0.51 | 24.3±0.47 | 37.73±0.56 | 30.5±0.78 | 26.3±0.27 | 41±1.1 | 33.5±0.51 | Serum creatinine (umol/l) | 10.67±0.44 | 15.97±0.53 | 23.81±0.95 | 11.1±0.52 | 16.02±0.59 | 26.7±0.39 | 13±0.43 | 17.28±0.61 | 27.±0.71 | BUN (mmol/l) | 5.9±0.39 | 8.36±0.20 | 9.74±0.12 | 6.60±0.36 | 7.60±0.19 | 11.13±0.25 | 6.54±0.13 | 8.79±0.14 | 11..51±0.18 | LDL (mmol/l) | 0.16±0.01 | 0.59±0.08 | 0.52±0.04 | 0.25±0.01 | 0.65±0.07 | 0.71±0.02 | 0.25±0.02 | 0.72±0.06 | 0.71±0.03 | Chol (mmol/l) | 2.01±0.08 | 4.41±0.08 | 4.17±0.16 | 2.16±0.09 | 5.58±0.18 | 5.26±0.18 | 2.20±0.38 | 5.68±0.07 | 5.15±0.13 |
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Data are expressed as the mean ± SEM. p<0.05 versus respective nondiabetic control. p<0.05 versus respective HFD control. p<0.05 versus WT with DM. |