The Emerging Role of lncRNAs in Spinal Cord Injury

Table 1

The differential expression profile of lncRNAs after SCI.

Published year	Animal	Model	Injury sites	Time point	Methods	Differentially expressed lncRNAs	Reference
2015	Rats	Contusion SCI	T10	1, 4, and 7 d	RNA sequencing	7 (lncSCIR1 constantly downregulated)	Wang et al. [34]
2016	Mice	Contusion SCI	T10	1 d, 3 d, 1 w, and 3 w	Microarray	Few changes in 1 d, peaked in 1 w and declined in 3 w	Ding et al. [36]
2016	Rats	SCI	T9	1 m, 3 m and 6 m	RNA sequencing	1 m: 137 (120 up, 17 down); 3 m: 239 (162 up, 77 down); 6 m: 179 (125 up, 54 down)	Duran et al. [39].
2017	Rats	Contusion SCI	T10	2 h	Microarray	772 (528 up, 244 down)	Zhou et al. [35]
2018	Rats	Contusion SCI	T10	2 d	Microarray	3193 (1332 up, 1,861 down)	Shi et al. [37]
2019	Mice	Standard Allen’s weight-drop model of SCI	T8-10	3 d	RNA sequencing	458 (356 up, 93 down)	Wang et al. [38]

d, day; h, hour; w, week; lncRNAs, long noncoding RNAs; m: month; SCI, spinal cord injury; T: thoracic level.