Propranolol Treatment for Infantile Hemangiomas: Short-Term Adverse Effects and Follow-Up to Age Two
Table 2
Adverse effects within 6-months of follow-up.
Classification
AEs
Cases with only one kind of AE
GI symptom
Sum = 40
Diarrhea▲
27
Increased stool frequency
5
Active bowel sound
1
Feeding difficulty
2
Original diarrhea aggravation
2
Blood-streak stool
1
Poor appetite
1
Vomit
1
CNS symptom
Sum = 15
Agitation
3
Hypoprosexia
1
Reduced total sleep time, increased night awakening time#
3
Somnolence#
2
Somnolence, reduced sleep time at night#
1
Reduced sleep time at night#
1
Restless sleep#
1
Increased night awakening time#
1
Insomnia-early#
1
Agitation, decreased total sleep time#▼
1
Cases with 2 kinds of AEs
Sum = 8
Diarrhea, agitation
1
Diarrhea, insomnia-early#
1
Diarrhea, hypoprosexia ◆
1
Active bowel sound, restless sleep#
1
Diarrhea, decreased total sleep#
1
Increased stool frequency; increased sleep time at night#
1
Severe diarrhea, vomit, feeding difficulty; agitation ▼
1
Severe diarrhea; decreased total sleep time#▼
1
Others
Sum = 7
Cold and sweaty hands and feet
2
Short of breath when the child cough
2
Cyanosis of lips
1
Hair thinning
1
Growth retardation
1
Sum diarrhea cases = 34 (48.57%), sum sleep disorder cases = 16 (22.86%), ▲1 case of this group drop-out, ▼3 other drop-out cases, ◆had diarrhea when propranolol was increased to 1 mg/kg/day, and hypoprosexia when propranolol was increased to 1.5 mg/kg/day, other 7 children’s adverse effects happened together, #belong to sleep disorder.
