Tankyrase Promotes Aerobic Glycolysis and Proliferation of Ovarian Cancer through Activation of Wnt/β-Catenin Signaling

Figure 7

The Oncogenic Activity of TNKS Exhibits through Wnt/β-Catenin Signaling. (a) Western blotting analysis of indicated protein levels after XAV939 and (or) Wnt 3a treatment. (b) Western blotting analysis of indicated protein levels after TNKS knockdown and (or) Wnt 3a treatment. (c) Dual-luciferase reporter assay of β-catenin/T-cell factor-responsive luciferase activity after XAV939 treatment or TNKS knockdown. (d) Western blotting analysis of snail and PC protein levels after sail knockdown and (or) Wnt 3a treatment. XAV939, 10 μM; Wnt 3a, 30 nM. n = 3 for each group. Data were expressed as the mean ± SD. , P < 0.05; , P < 0.01.

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