Tankyrase Promotes Aerobic Glycolysis and Proliferation of Ovarian Cancer through Activation of Wnt/β-Catenin Signaling

Figure 6

PC Mediates TNKS-Regulated Aerobic Glycolysis. (a) Western blotting analysis of aerobic glycolysis associated proteins levels after TNKS inhibition or knockdown. (b-e). Effect of PC overexpression on the cellular glucose uptake (b), lactate release (c), ATP levels (d), and O₂ consumption rates (e) were measured in TNKS inhibition or TNKS knockdown OVCAR-3 cells. XAV939, 10 μM. n = 3 for each group. Data were expressed as the mean ± SD. , P < 0.05.