Tankyrase Promotes Aerobic Glycolysis and Proliferation of Ovarian Cancer through Activation of Wnt/β-Catenin Signaling

Figure 5

TNKS is Critical for Glycolytic Activity of Ovarian Cancer Cells. Cellular glucose uptake (a), lactate release (b), ATP levels (c), and O₂ consumption rates (d) were measured in A2780 and OVCAR-3 cells after XAV939 treatment for 24 h or TNKS knockdown in the OVCAR-3 cells. XAV939, 10 μM. n = 3 for each group. Data were expressed as the mean ± SD. , P < 0.05; , P < 0.01.

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