Tankyrase Promotes Aerobic Glycolysis and Proliferation of Ovarian Cancer through Activation of Wnt/β-Catenin Signaling

Figure 4

The Role of TNKS in the Migration and Invasion of Ovarian Cancer Cells. (a) Cell migration was detected by wound-healing assay. Representative microphotographs at 0 h and 48 h after wounding (top) and a plot of the cell-free area within the wound are shown (bottom). (b) Cell migration (without matrigel) and invasion (with matrigel) were detected by transwell analysis. Representative microphotographs at 48 h after XAV939 treatment or TNKS knockdown (top) and the calculated number from triplicates are shown (bottom). XAV939, 10 μM. Data were expressed as the mean ± SD. , P < 0.05; , P < 0.01.

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