Tankyrase Promotes Aerobic Glycolysis and Proliferation of Ovarian Cancer through Activation of Wnt/β-Catenin Signaling

Figure 3

The Role of TNKS in Cell Cycle and Apoptosis of Ovarian Cancer Cells. (a) Cell cycle analysis of OVCAR-3 cells after XAV939 treatment or TNKS knockdown performed by flow cytometry. (b) The drug susceptibility of OVCAR-3 cells to taxane and CDDP after TNKS inhibition or knockdown detected by MTS. (c) Cell apoptosis analysis detected by flow cytometry through Annexion V/PI double-staining method. XAV939, 10 μM. n = 3 for each group. Data were expressed as the mean ± SD. , P < 0.05; , P < 0.01.

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