Tankyrase Promotes Aerobic Glycolysis and Proliferation of Ovarian Cancer through Activation of Wnt/β-Catenin Signaling

Figure 1

Expression of TNKS in Clinical Ovarian Cancer Tissues. (a) The levels of TNKS mRNA in ovarian cancer and normal ovarian surface epithelium tissues (left), and different histopathological types. The data are obtained from Bonome Ovarian Statistics and Hendrix Ovarian Statistics of Oncomine database, respectively. (b) Real-time PCR analysis of TNKS mRNA levels in clinical ovarian cancer and paracancerous tissues. (c) Western blotting analysis of TNKS1 protein levels in 23 clinical ovarian cancer and paracancerous tissues. GAPDH was used to indicate the amount of loading proteins. (d) Representative IHC of TNKS protein in C, P, and N tissues. Four different grades (-, +, 2+, and 3+) of staining intensity were according to their different positive rates of TNKS expression. Scale bar: 50 μM. C: cancer; P: paracancerous; N: normal.

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