Association Study of the Caspase Gene Family and Psoriasis Vulgaris Susceptibility in Northeastern China
Table 3
The single SNP association studies result of CASPs in cases and controls.
Gene Symbol
Genotype
Cases (n=540)
Controls (n= 612)
H-W P Value
P Value
Adjusted P Value
Statistical Model
P
P’
OR (95%CI)
CASP1
rs2282659
GG
24(0.044)
30(0.049)
Additive
0.8650
0.8813
GA
164(0.304)
196(0.320)
0.7871
0.5945
0.6279
Dominant
0.7952
0.8528
1.083
AA
352(0.652)
386(0.630)
Recessive
0.5977
0.6057
(0.812,1.444)
G/A
212/868
256/968
heterozygous
0.6687
0.7222
0.196/0.804
0.209/0.791
CASP3
rs2705897
TT
350(0.648)
430(0.703)
Additive
0.3765
0.3845
TG
172(0.319)
164(0.268)
0.8629
0.1953
0.2205
Dominant
0.1632
0.1833
1.221
GG
18(0.033)
18(0.029)
Recessive
0.7874
0.8057
(0.902,1.653)
T/G
872/208
1024/200
heterozygous
0.1832
0.2056
0.807/0.193
0.837/0.163
rs4647610
TT
222(0.411)
274(0.448)
Additive
0.5322
0.5412
TC
248(0.459)
274(0.448)
0.1773
0.2700
0.2857
Dominant
0.3758
0.4025
1.147
CC
70(0.130)
64(0.105)
Recessive
0.3498
0.3586
(0.899,1.463)
T/C
692/388
822/402
heterozygous
0.7812
0.7998
0.641/0.359
0.672/0.328
CASP4
rs547584
TT
368(0.681)
434(0.709)
Additive
0.5413
0.5451
TC
152(0.282)
164(0.268)
0.886
0.3451
0.3884
Dominant
0.4714
0.5293
1.162
CC
20(0.037)
14(0.023)
Recessive
0.3164
0.3403
(0.852,1.585)
T/C
888/192
1032/192
heterozygous
0.7170
0.7835
0.822/0.178
0.843/0.157
rs672016
GG
20(0.037)
30(0.049)
Additive
0.5789
0.5968
GC
206(0.382)
212(0.346)
1
0.8180
0.8317
Dominant
0.4794
0.5470
0.969
CC
314(0.581)
370(0.605)
Recessive
0.5734
0.6178
(0.734,1.278)
G/C
246/834
272/952
heterozygous
0.3824
0.3873
0.228/0.772
0.222/0.778
CASP5
rs507879
TT
366(0.678)
402(0.657)
Additive
0.6168
0.6265
TC
156(0.289)
180(0.294)
1
0.4362
0.4632
Dominant
0.5950
0.5992
0.886
CC
18(0.033)
30(0.049)
Recessive
0.3439
0.4141
(0.658,1.194)
T/C
888/192
984/240
heterozygous
0.8904
0.9258
0.822/0.178
0.804/0.196
CASP6
rs5030545
TT
2(0.004)
0(0)
Additive
0.4295
0.6065
TC
86(0.159)
106(0.173)
0.886
0.8369
0.9111
Dominant
-
0.9998
1.043
CC
452(0.837)
506(0.827)
Recessive
0.7430
0.8257
(0.688,1.580)
T/C
90/990
106/1118
heterozygous
0.6538
0.6495
0.083/0.917
0.087/0.913
CASP7
rs17090911
GG
442(0.819)
526(0.860)
Additive
0.36448
0.4247
GA
94(0.174)
84(0.137)
0.8727
0.1609
0.1908
Dominant
0.1810
0.2086
1.346
AA
4(0.007)
2(0.003)
Recessive
0.4888
0.6035
(0.884,2.051)
G/A
978/102
1136/88
heterozygous
0.2229
0.2461
0.06/0.094
0.928/0.072
rs2227310
GG
104(0.193)
88(0.144)
Additive
0.2164
0.2147
GC
260(0.481)
294(0.480)
0.5244
0.0894
0.0919
Dominant
0.1172
0.1432
0.815
CC
176(0.326)
230(0.376)
Recessive
0.2106
0.2184
(0.644,1.032)
G/C
468/612
470/754
heterozygous
0.9792
0.9998
0.433/0.567
0.384/0.616
CASP8
rs6704688
TT
40(0.074)
24(0.039)
Additive
0.0169
0.0179
TC
170(0.315)
254(0.415)
0.8725
0.5429
0.5777
Dominant
0.0679
0.0974
1.088
CC
330(0.611)
334(0.546)
Recessive
0.1129
0.1258
(0.829,1.427)
T/C
250/830
302/922
heterozygous
0.0126
0.0149
0.231/0.769
0.247/0.753
rs2293554
TT
332(0.615)
358(0.585)
Additive
0.6952
0.6784
TG
178(0.329)
212(0.346)
0.546
0.3999
0.4151
Dominant
0.4656
0.4911
0.886
GG
30(0.056)
42(0.069)
Recessive
0.5166
0.6077
(0.673,1.167)
T/G
842/238
928/296
heterozygous
0.6711
0.7163
0.780/0.220
0.758/0.242
CASP9
rs4233532
TT
176(0.326)
224(0.366)
Additive
0.2005
0.2144
TC
278(0.515)
270(0.441)
0.0447
0.9114
0.9544
Dominant
0.3129
0.3380
1.013
CC
86(0.159)
118(0.193)
Recessive
0.2915
0.3272
(0.801,1.281)
T/C
630/450
718/506
heterozygous
0.0773
0.0821
0.584/0.416
0.587/0.413
rs1052576
TT
70(0.130)
98(0.160)
Additive
0.2790
0.2851
TC
258(0.478)
254(0.415)
1
0.9761
0.9999
Dominant
0.2994
0.3467
0.996
CC
212(0.392)
260(0.425)
Recessive
0.4321
0.4519
(0.784,1.266)
T/C
398/682
450/774
heterozygous
0.1304
0.1623
0.369/0.631
0.368/0.632
CASP10
rs12613347
TT
74(0.137)
82(0.134)
Additive
0.9752
0.9714
TC
238(0.441)
266(0.435)
0.6406
0.8325
0.8550
Dominant
0.9150
0.9998
0.974
CC
228(0.422)
264(0.431)
Recessive
0.8247
0.8681
(0.764,1.240)
T/C
386/694
430/794
heterozygous
0.8829
0.9316
0.357/0.643
0.351/0.649
rs13006529
TT
342(0.633)
366(0.598)
Additive
0.0846
0.0806
TA
164(0.304)
226(0.369)
0.4431
0.9179
0.9452
Dominant
0.3849
0.3863
0.985
AA
34(0.063)
20(0.033)
Recessive
0.0856
0.1072
(0.744,1.305)
T/A
848/232
958/266
heterozygous
0.0965
0.1112
0.785/0.215
0.783/0.217
CASP12
rs506601
TT
48(0.089)
48(0.078)
Additive
0.5086
0.5049
TA
230(0.426)
290(0.484)
0.6716
0.6101
0.6427
Dominant
0.6507
0.7603
1.065
AA
262(0.485)
274(0.448)
Recessive
0.3682
0.4018
(0.829,1.369)
T/A
326/754
386/838
heterozygous
0.2485
0.2688
0.302/0.698
0.315/0.685
CASP14
rs3181304
GG
120(0.222)
104(0.170)
Additive
0.2007
0.2129
GA
230(0.426)
298(0.487)
1
0.4686
0.4826
Dominant
0.1139
0.1425
0.915
AA
190(0.352)
210(0.343)
Recessive
0.8265
0.8582
(0.724,1.156)
G/A
470/610
506/718
heterozygous
0.1424
0.1547
0.435/0.565
0.413/0.587
: Significant, compared by paired t test; H-W: Hardy–Weinberg equilibrium test; P: model-based statistical p value; P’: p value adjusted by permutation; OR: odds ratio; and 95%CI: 95% confidence interval.
