Plasma and Renal Cortex Meropenem Concentrations in Patients Undergoing Percutaneous Renal Biopsy

Figure 2

Theoretical mK/mP ratio and concentration decay curves. As long as the eGFR remains constant, the filtered load will depend on “mP” over time. The higher the plasma concentration, the higher the filtrate, determining first-order elimination. Thus, the relation mU/mP will be equivalent to a constant (K1) over time. This determines that the remaining concentration in the kidney will also be maintained at a constant rate over time (mK/mP = K2). With this in mind, and assuming that the ratio mK/mP is 0.14, we can graph the decay curve and thus estimate the doses necessary to achieve the MIC-90 in the renal parenchyma. mK: kidney meropenem concentration; mP: plasma meropenem concentration; mU: urine meropenem concentration.

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