Research Article

Different Membrane Pathways Mediate Ca2+ Influx in Adrenal Chromaffin Cells Exposed to 150–400 ns Electric Pulses

Table 1

Effect of blocking VGCCs on 150 ns pulse-induced increases in .

VGCC blockerRelative fluorescence intensity Reduction in amplitude (%)- test ( value)
ControlVGCC blocked

ω-Agatoxin GVIA (100 nM)24
ω-Conotoxin (20 nM)9NS
Nimodipine (5 μM)0
Nitrendipine (5 μM)0
48
Nimodipine (20 μM)53
Nitrendipine (20 μM)62
67

Nitrendipine at 5 μM; nitrendipine at 20 μM; NS: not significant.