Coronary Atherosclerosis Assessment by Coronary CT Angiography in Asymptomatic Diabetic Population: A Critical Systematic Review of the Literature and Future Perspectives

Table 1

Randomized studies that investigated the prognostic power of CCTA in asymptomatic or stable patients with diabetic mellitus versus nondiabetics.

Authors/journal	Diabetics	Nondiabetics	Follow-up	Events in diabetics	Events in nondiabetics	Characteristic of CAD at CCTA	Univariate analysis in diabetics (HR)	Multivariate analysis in diabetics (HR)	Univariate analysis in nondiabetics (HR)	Multivariate analysis in nondiabetics (HR)
Van Werkhoven et al./Radiology 2010 [44]			months	Total cardiac events (88)	Total cardiac events (45)	Obstructive	6.57		16.29	21.64
Rana et al./Diabetes Care 2012 [6]			26 months	Death (3.2%)	Death (1.7%)	Nonobstructive		5.25		3.12
						(1) Vessel disease		6.39		5.56
						(2) Vessel disease		12.33		7.87
						(3) Vessel disease		13.25		9.25
Nadjiriet et al./Int J Cardiovasc Imag 2015 [45]			months	Cardiac events  (annual cardiac event rate 1.74%)		Number of lesions per patient (SIS)		3.0
						Segment stenosis score (SSS)		4.5
					Cardiac events  (annual cardiac event rate 0.64%)	Number of lesions per patient (SIS)				1.31
						Segment stenosis score (SSS)				1.3
Blanke et al./Jacc CI 2016 [46]			60 months	Death (13.5%)	Death (7.5%)		RR for all-cause mortality in diabetics compared with propensity matched nondiabetics stratified according to extent/severity of CAD
						Nonobstructive	2.09
						Obstructive	1.95
						(1) Vessel disease	1.48
						(2) Vessel disease	2.45
						(3) Vessel disease	2.31

CAD: coronary artery disease; CCTA: coronary computed tomography angiography; HR: hazard ratio; RR: relative risk.