UCHL1/PGP 9.5 Dynamic in Neuro-Immune-Cutaneous Milieu: Focusing on Axonal Nerve Terminals and Epidermal Keratinocytes in Psoriatic Itch

Figure 2

PGP 9.5 distribution and expression in axonal nerve terminals and dermal nerve fibers in skin samples of healthy individuals and nonlesional and lesional skin of psoriasis with or without itch. PGP 9.5 of epidermal axonal nerve terminals and dermal fibers in normal healthy skin analyzed by indirect immunofluorescence staining on frozen skin sections (a). The nonlesional (b) and lesional skin (c) with itch (Itch+), in relation to nonlesional (d) and lesional skin (e) without itch (Itch-) from psoriasis patients. Axonal nerve terminal and dermal nerve fibers marked with red arrows. Scale bars represent 100 μm.

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