A Comparative In Vivo Study on Three Treatment Approaches to Applying Topical Botulinum Toxin A for Crow’s Feet

Table 1

Comparison of clinical effect on dynamic wrinkles before and after treatment ().

Group	Baseline	1 week	4 weeks	12 weeks
intramuscular injections
intradermal Microdroplet
nanomicroneedles
value	0.257	34.911	31.298	10.857
value	>0.05	<0.05	<0.05	<0.05

Note: compared with baseline; compared with intramuscular injections group at the same time point; compared with intradermal microdroplet group at the same time point; compared with nanomicroneedle group at the same time point.