In Vitro Susceptibility of Mycobacterium abscessus and Mycobacterium fortuitum Isolates to 30 Antibiotics

Table 2

Breakpoints of 30 antibiotics.

Antimicrobial Agent		MIC breakpoints (μg/ml)
		Susceptibility	Intermediate	Resistance
Macrolides	CLR	⩽2	4	⩾8
	AZM	⩽2	4	⩾8
Rifamycins	RIF	-	-	>1
	RFB	-	-	>2
Aminoglycosides	STR	-	-	⩾5
	GEN	<=4	8	>=16
	KAN	-	-	⩾4
	TOB	⩽2	4	⩾8
	NEO	-	-	>=10
	AMK	⩽16	32	⩾64
Fluoroquinolones	MXF	⩽1	2	⩾4
	CIP	⩽1	2	⩾4
	LVX	⩽2	4	⩾8
Cephalosporin	FOX	⩽16	32-64	⩾128
	CMZ	⩽16	32	⩾64
Tetracyclines	TCY	<=4	8	>=16
	DOX	⩽1	2-4	⩾8
	MNO	⩽1	2-4	⩾8
Glycylcycline	TGC	⩽1	2-4	⩾8
Sulfonamides	SOX	⩽38	-	⩾76
Carbapenems	IMP	⩽4	8-16	⩾32
Oxazolidinones	LNZ	⩽8	16	⩾32
Lincosamides	CLI	<=0.5	1-2	>=4
Penicillins	OXA	<=2	-	>=4
Polypeptides	TEC	<=8	16	>=32
	VAN	<=2	4-8	>=16
Others	CFZ	-	-	>1
	INH	-	-	⩾1
	EMB	-	-	⩾4
	ETH	-	-	>5

a denotes the breakpoints coming from Susceptibility Testing of Mycobacteria, Nocardia, and Other Aerobic Actinomycetes; Approved Standard–Second Edition. CLSI document M24-A2.
b denotes the breakpoints coming from Performance Standards Antimicrobial Susceptibility Testing-27th Edition. CLSI document M100.
c, d, e denote the breakpoints coming from [18–20], respectively.
d, S, susceptible, I, intermediate susceptible, and R, resistant.